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Concurrently, Mtb undergoes metabolic reprogramming to survive under these hostile conditions, facilitating a shift to a non-replicating persistent (NRP) state

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The frequency of adverse reactions have been reported to be between 0.2% and 21%, and they most commonly occur during the initial loading dose of acetylcysteine

Variants in genes affecting glutathione metabolism, oxidative stress responses, and metabolic inflammation may help provide context for why certain patients respond more robustly to supplementation strategies

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