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Topical applications may not penetrate adequately

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In further embodiments, the invention encompasses a method of providing muscular therapy by administering a therapeutically effective amount of one or more cations of the invention and one or more cations chosen from Tables 3a and 3b

[36] Antibodies to intrinsic factor and parietal cells cause the destruction of the oxyntic gastric mucosa, in which the parietal cells are located, leading to the subsequent loss of intrinsic factor synthesis

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The evidence is clear: for most patients, high-dose oral supplements are as effective as injections