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Consequently, PHGDH suppresses c-JUN poly(ADP-ribosyl)ation by both limiting NAD availability and directly binding to c-JUN, thereby blocking c-JUNdriven proliferation [115]

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In vivo , C75 treatment restored endothelial function and reversed erectile dysfunction, accompanied by decreased oxidative stress and pyroptosis in the penile corpus cavernosum

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doi: 10.1016/j.celrep.2022.110976 211 HaacMEAndersonMAEgglestonHMylesKMAdelmanZN

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