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Multiple gene therapy strategies utilizing patients own stem cells, are also being pursued, but this has the disadvantage of myeloablative conditioning ( In addition to great advances in HSCT and gene therapy, new pharmacological anti-sickling approaches have developed

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Am J Physiol 257(4 Pt 1):L163L173 Dey A, Kessova IG, Cederbaum AI (2006) Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1

When extracellular arginine is depleted, citrulline can be imported into the cell and recycled to arginine via argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl) 19

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