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The liver detoxifies xenobiotics and endogenous waste products through conjugation reactions, but fat metabolism (lipolysis and beta-oxidation) is regulated by insulin, glucagon, epinephrine, and adipose tissue lipase activity

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More importantly, treatment with APG-157 led to a reduction in pro-inflammatory cytokines IL-1, IL-6, and IL-8 in the saliva of these cancer patients ( A Phase II trial (ongoing or recently completed) is testing APG-157 in combination with a checkpoint inhibitor (immunotherapy) in oral cancer, based on preclinical suggestions that curcumin may improve anti-tumor immunity (Xiang et al., 2019)

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Although several questions, such as the mechanism of the overexpression of GPX4, remain unsolved, and prospective studies must be performed with regard to potential clinical applications, GPX4 has the potential to become a novel anticancer drug target, as well as a prognostic predictor