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To avoid drug interactions, the study population should initially consist of older CAP patients without comorbidities, then expand to include those with one or more comorbidities, malnutrition, or immunodeficiencies

But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

J.TorzewskiJ.EgashiraK.et al (2005)

Huse A, Lindmark GM, Srensen PL, Heie , Weholt , Mroueh U, Wahlstrm M (1999) Categories and Quantities of mercury waste, and treatment capacity in the Nordic countries

Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men