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These effects indicate that Scrophulariae Radix exerts systemic regulatory effects on thyroid hormone metabolism through multiple targets and pathways, optimizing energy and material metabolism and alleviating the metabolic burden in hyperthyroidism

In a positive feedback loop, IL-13 and TRMP5 induces differentiation of epithelial cells (IECs) into more tuft cells

CD36 senses dietary lipids and regulates lipids homeostasis in the intestine

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Tissue sections were incubated with primary mouse antibodies FITC anti-CD192 (1:100 dilution) (CCR2) (BioLegend, 150607), PE anti-CD11b (1:200 dilution) (BioLegend, 101208), anti-CD68 (1:200 dilution) (BioLegend, 137001), anti-F4/80 (1:200 dilution) (BioLegend, 123101), and anti-IL-6 (D5W4V) (1:200 dilution) (Cell Signaling 12912S) overnight, stained with secondary antibody (for CD68, F4/80, IL-6) (Invitrogen SA5-10018, A21434 and A11036)

Additional platforms exploit GSH-mediated cleavage of disulfide or polysulfide bonds to induce ferroptosis and pyroptosis