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Therefore, TMAO induced activation of the NF-B signaling pathway may be an important cause of IBD pathogenesis

Beyond its role in fat metabolism, L-Carnitine also supports muscle function and helps regulate glucose metabolism, making it an essential nutrient for overall energy and metabolic health

Furthermore, TMAO exacerbates VC through dose-dependent vascular smooth muscle cell calcification and activation of the NLRP3 inflammasome and NF-B signaling (Zhang et al., 2020), thereby further promoting thrombosis (Figure 6)

doi: 10.1016/j.biopha.2017.11.016 47 GetzG

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came to the same conclusion