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It was also found to interact with Leu102, Tyr122, Thr129, Met132, and Trp133 residues of chain-A by hydrophobic interactions

Despite this, the anti-tumor efficacy of PLD is still limited due to low stability, insufficient availability, or uncontrolled and inadequate release of the encapsulated drug at the tumor site 6,7

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Most cases of familial GC exhibits a diffuse histopathology and mutations in the E-cathedrin ( CDH-1 ) gene is the major cause of this disease

therapeutic treatment with P2Et polyphenol-rich extract has opposite effects on tumor growth

Nevertheless, patients should be aware of a small risk of transmitting generalized disease to their descendents.28,30 It is important to highlight that gonadal mosaicism is independent of the site of the affected cutaneous area, which is not necessarily localized on or near the gonadal region