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However, as the disease progresses, sustained abnormal glial activation triggers the overactivation of signaling pathways such as NF-B and p38 MAPK, leading to the excessive release of pro-inflammatory cytokines (e.g., IL-1, TNF-, IL-6) (Newcombe et al., 2018

Subsequently, caspase-1 cleaves GSDMD, releasing the GSDMD-NT fragment, which induces pore formation, cell swelling, and ultimately pyroptosis [82]

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The department's organization and resources are complex, including 21 community stations (divisions) grouped in four bureaus under the Office of Operations

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