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In sepsis-induced AKI, the accumulation of lactic acid in renal tubules activates the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis, leading to lymphocyte apoptosis and contributing to immunosuppression ( In addition, lipid-derived mediators produced from the autoxidation of intracellular polyunsaturated FAs, such as -linolenic acid and docosahexaenoic acid (DHA), exhibit anti-inflammatory effects ( 4.3 Facilitation of renal fibrosis Renal fibrosis represents the final common pathological outcome in most CKD cases, with epithelial injury and aberrant repair processes serving as central events in its progression

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B vitamins play a critical role in how the body converts nutrients into energy and supports essential processes that keep your body and mind performing optimally