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The combination of these findings positioned NNMT as a candidate metabolic-disease and metabolic-aging research target, motivating development of selective small-molecule inhibitors including 5-Amino-1MQ

Mice were euthanized in a non-fasted state over 2 days during their sleep cycle

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5AM-1MQ OVERVIEW Category: Small Molecule / Selective Enzyme Inhibitor (NNMTi) How It Works: Selectively inhibits the Nicotinamide N-methyltransferase (NNMT) enzyme to increase cellular NAD+ levels and metabolic expenditure