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However, despite low plasma concentrations, pharmacokinetic studies show that berberine has a high tissue distribution rate, accumulating effectively in the liver, kidneys, muscle, and heart where it exerts its metabolic effects

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This raises the question of whether sex hormones could provide a bridge to understanding common etiologies of these conditions, in some neonates, occurring through differing gender-dependent mechanisms of pathogenesis

10.1016/j.mce.2003.10.069 56 VukoviA

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These findings open new avenues for therapeutic interventions in breast cancer, emphasizing the interconnected roles of metabolism and immunity in cancer progression