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About this article Cite this article Xue, L., Gui, J., Pan, H

Triptolide attenuates cancer cells by regulating the process of autophagy and ferroptosis Triptolide has been shown to exhibit antitumor effects in ovarian cancer (SK-OV-3 and SK-OV-3/DDP) cells by inducing autophagy through ROS generation and JAK2/STAT3 pathway inhibition, enhancing chemotherapy sensitivity and inhibiting tumor growth, as well as by inducing apoptosis and reducing the protein expression of MMP-2, Sorcin, and VEGF, thereby disrupting the Mcl-1/Beclin1 interaction and highlighting its multifaceted therapeutic potential [991, 992]