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Under normal physiological conditions, axonal mitochondria of long-projection neurons are enclosed in axoplasmic membranes, which are then shed and degraded by neighboring cells ( Mitophagy in neurons The human brain, despite accounting for only 2% of the bodys volume, is responsible for 25% of its oxygen consumption

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Although these preliminary data warrant further validation, these observations suggest that complement-targeted regulation before, during and after organ retrieval could modulate aberrant inflammation, regulating the IRI cytokine storm thus limiting renal damage and improving the outcome of transplantation

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