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The process of oxidation deactivates an antioxidant, and makes it a pro -oxidant unless it is gifted with a stabilising electron from another source

In our previous study, pharmacokinetic and pharmacodynamic analyses ( n = 145) demonstrated that L-serine exhibited greater efficacy at higher doses, with regimens equivalent to 400 mg/kg/day leading to notable increases in K-VABS-II-ABC scores (1.73.7 points vs

Kondo K, Hashimoto H, Kitanaka J, Sawada M, Suzumura A, Marunouchi T, et al

Another small study evaluating pregabalin for restless leg syndrome in patients with cirrhosis found that treatment discontinuation commonly occurred at higher doses due to adverse effects [54]

Shen, S., Ji, C

Nat Neurosci 25: 688701, 2022