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It may be that exercise enhances the catalytic efficiency of antioxidant enzymes, allowing the body to maintain similar antioxidant capacity while producing fewer enzymes, which could be related to adaptive changes resulting from long-term exercise

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The application of multi-OMICS approaches are gaining acceptance in the regulatory community to provide information on a chemicals hazard and risks though their mode-of-action (MOA), however, its utility in a AOP building context are still limited

Chronobiological studies have shown that RSV decreases lipid peroxidation when administered during the dark phase but increases it during the light phase, highlighting the importance of timing in its therapeutic application (24)

The patients showed a pronounced deficit in total serum Se and SELENOP concentrations when compared to reference data from a cross-sectional analysis of the European EPIC study (Reference Moghaddam, Heller and Sun40)

added that APOE- 4 is a risk factor, and that patients that are homozygous to this allele will be 8 times more prone to develop AD (Yokoyama et al., 2017)