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Clamping the internal Ca 2+ in individual CA1 astrocytes has been shown to block LTP in excitatory synapses by reducing the occupancy of the NMDAR co-agonist sites (Henneberger et al., 2010

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NNMT is upregulated in white adipose tissue in obesity and in cancer cachexia models, and NNMT enzymatic activity has been implicated in maintaining the adipocyte fat-storage phenotype through SAM-dependent epigenetic remodeling

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J Biol Chem 286: 3200232010

Photo Credit: Shutterstock Glutathione inhibits tyrosinase, an enzyme involved in melanin production, and transforms darker pigments into lighter ones