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Ayaydn H, Klaslan F, Koyuncu , elik H, alk M, Gzeliek A, Kirmit A (2021) Impaired thiol/disulfide homeostasis in children diagnosed with autism: a case-control study

FIGURE 2 4.1 Ferroptosis promotes pancreatic tumour and hepatocellular carcinoma development and progression by regulating metabolic pathways ACSL4, an enzyme involved in synthesizing phospholipids from PUFAs plays a crucial role in ferroptosis (Yuan et al., 2016)

Increasing extracellular glutamate levels limits the uptake of cystine, gradually inducing ferroptosis

Thus, while it is clear that agonism of Hcar2 by niacin or other compounds leads to an increase in intracellular Ca 2+ and a reduction in inflammation, the specific pathways remain to be fully elucidated

doi: 10.1136/annrheumdis-2014-207169 43