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Furthermore, oncogenic KRAS is associated with numerous metabolic processes, including induced glucose uptake, re-utilization of glutamine metabolism, and increased autophagy and macropinocytosis

The beneficial biological activities of flavonoids are undoubtedly related to their structural composition and attributes

J.KallaR.HoG

[A peer review file is available]

Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences

FTH1 can convert Fe 2+ into Fe 3+ , binds to FTL to reduce the toxicity of intracellular Fe 2+ , thus preventing ferroptosis to occur