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Disclosures: Angela Sato Espinoza: Nothing to Disclose, Perapa Chotiprasidhi: Nothing to Disclose, Kirk Wangensteen: Nothing to Disclose 2555 INTEGRATION OF BULK RNA-SEQ AND SCRNA-SEQ REVEALS MOLECULAR MECHANISMS AND TUMOR MICROENVIRONMENT BEHIND DIFFERENCES IN CLINICOPATHOLOGIC CHARACTERISTICS OF HEPATOCELLULAR CARCINOMA PATIENTS WITH DIFFERENT TUMOR MARKER COMBINATIONS Zheyu Zhou 1 Jinsong Liu 2 Chaobo Chen 3 Shuya Cao 4 Ke Wang 4 Beicheng Sun 5 Xiaoliang Xu 5 , 1 Nanjing Drum Tower Hospital, 2 Xinhua Hospital, 3 Xishan People's Hospital of Wuxi City, 4 Nanjing Medical University, 5 Anhui Medical University Background: Efficient biomarkers are needed to guide precision therapy to improve hepatocellular carcinoma (HCC) patients' prognosis and 5-year survival