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These are the reasons why there was no USFDA approval of Vitamin C injection for cosmetics, especially as anti-ageing, whitening agent and anti-wrinkle

This is primarily through the secretion of cytokines associated with type_2 IRs (Hendel et al

Limitations include high cost, ethical constraints, limited generalizability, underpowered sample sizes, and challenges in blinding participants or clinicians in certain interventions (e.g., physical therapy)