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Direct effects on cellular proliferation A genetically engineered murine model of pancreatic intraepithelial neoplasia (PanIN) to PDAC progression ( LSL-Kras G12D ;Pdx1-Cre, KC ) treated with exenatide demonstrated architectural changes of loss of polarity and micropapillary formation following 12 weeks of therapy 18

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A subset of prescribers combine oral and subcutaneous administration simultaneously (e.g., 250 mcg oral in the morning plus 250 mcg subcutaneous in the evening)

Clin Chem (1999) 45(2):2902