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Experimental preclinical doses in rodents range 100 to 500 g/kg/day

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Xie X, Yu H, Wang Y, Zhou Y, Li G, Ruan Z, Li F, Wang X, Liu H, Zhang J (2014) Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells

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This process depletes cellular NAD+ and S-adenosylmethionine (SAM) two critical molecules for energy metabolism and cellular function

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