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Since GPX4 is critical for neutralizing lipid peroxides, enhancing GPX4 function or ensuring an ample supply of its substrate GSH can significantly lower ferroptosis incidence

The cells were further incubated for the indicated periods

A 12-week study with rats treated with up to 200 mg/kg/day showed no adverse effects on hematological, biochemical, or organ-specific parameters, confirming its tolerability

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This recommendation, which has since been updated in the GOLD 2023 Report [29], was based primarily on the evidence available for each mucolytic agent at that time

Seidel et al., 2019)