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Myung, S

Neuroactive metabolites The gut microbiota synthesizes dopamine precursors (such as tyrosine metabolites) and gamma-aminobutyric acid (GABA), which directly affect the function of the nigro-striatum pathway

also found that compared to the control group, the serum levels of interleukin (IL)-6 and IL-21 in the primary ovarian failure (POF) group were significantly higher (Sun et al., 2018)

Serotonin syndrome signs and symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)

doi: 10.1126/sciadv.abg3188

Understanding how these local niches influence persister formation will be critical for pinpointing vulnerabilities we can actually target