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However, the concentrations of several crucial biomarkers in patient samples often fall below the detection limits of these conventional laboratory methods

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Most of the risks of these compounds stem from the absence of clinical trials and reliable data in humans, making it impossible to establish appropriate dosing, long-term safety, or adverse event profiles

In patients with enthesitis or axial disease refractory to NSAID therapy, there is little evidence for benefit with nonbiologic DMARDs, so that TNF inhibitor therapy may be warranted in this situation

Studies examine its action in tissue repair after injuries, acceleration of wound healing, and support for the body during recovery periods