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Our finding that LDHB silencing activates STAT1, a key effector of the INF-/JAK pathway, which suppresses the expression of SLC7A11 is plausibly consistent with the notion that LDH has additional roles beyond glycolysis [23], although the possibility that lactate rather than LDHB itself modulates INF-/JAK pathway activity cannot be completely excluded [67]

(2001) Science 294: 1537- 1540

doi: 10.1021/acs.molpharmaceut.0c00337, 16 ChurchF

When the growth phase lasts longer, each hair has more time to thicken before shedding

Evidence across experimental models In vitro Cell models show strong initial responses followed by rapid attenuation with repeated stimulation

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