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All this to say, these are competitive results however the rates of diarrhea and vomiting could be a problem if they continue to develop the 6mg dose, and for Kailera, they need to conduct trials in the United States and elsewhere

This adds to the difficulty in reconciling MS under a single pathophysiological umbrella, but also has implications for therapeutic design: this cytodegenerative component is not expected to respond to current anti-inflammatory disease-modifying drugs targeting acute/adaptive peripheral autoimmunity

Interestingly, we see marginal release of cytochrome c following 5FU and a transient dip in MOMP, but no enhanced difference in sensitivity to BH3-mimetics or increase in ATF4 expression or predicted activity in RNA-seq analysis (data not shown)

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Moderate deficiency causes peripheral neuropathy, characterized by numbness, tingling, and weakness in the hands and feet

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