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Description

The alkenyl group of dopamine acrylamide can be coupled to thiol-modified DNA by thiol-ene click reaction

This molecular mechanism can be attributed to the spongelike activity of UCA1, as it sequesters miR16 and blocks it from attaching to the GLS2 mRNA's 3'UTR region, thereby inhibiting the degradation of GLS2 mRNA (Figure 2F) [189]