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Should You Consider Taking A Vitamin B12 Supplement With Metformin? Why Metformin Users Need to Monitor Vitamin B12 Should You Take Vitamin B12 With Metformin? Metformin Led to Vitamin B12 Loss and Excruciating Pain The People's Pharmacy Should I take a B12 supplement while on Metformin? If you have been on Metformin for several years, monitoring is essential. The B12 Link: Long term use (typically 4+ years) can interfere with Vitamin B12 absorption. Symptoms to Watch: Fatigue, memory issues
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