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GN disrupts the metabolism of phospholipids in tubular cells

IP 3 -sensitive Ca 2+ stores can be activated by G protein-coupled receptors such as Group I metabotropic glutamate receptors (mGluRs) or muscarinic acetylcholine receptors, which activates phospholipase C (PLC), which in turn cleaves phosphatidylinositol biphosphate (PIP 2 ), causing the release of diacylglycerol (DAG) and IP 3

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Instruct patients of the requirement to take corticosteroids to reduce the risks of treatment-related toxicity [see Dosage and Administration (2.4)and Warnings and Precautions (5.1)]

Relations between von Willebrand factor, markers of oxidative stress and microalbuminuria in patients with type 2 diabetes mellitus