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Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia

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Abbreviations PsA: Psoriatic arthritis PsO: Psoriasis RA: Rheumatoid arthritis HC: Healthy control CASPAR: ClASsification for psoriatic ARthritis DAPSA: Disease activity PsA PCA: Principal component analysis OPLS-DA: Orthogonal partial least squares discriminant analysis VIP: Variable influence on projection ROC: Receiver operator characteristic curves AUC: Area under the curve DT2: Diabetes type 2 BCAAs: Branched-chain amino acids CRP: C-reactive protein GSH: Glutathione Trp: Tryptophan References Ritchlin, C

et al, 2023)

Madaio was corresponding author of a study this summer also in Kidney International that showed that using the same antibody, this time to deliver the anti-inflammatory protein kinase C-alpha inhibitor directly to the kidney, enabled the organs recovery in a similar model of nephritis

FA is an aggregate index of WM integrity, which is thought to reflect fiber density, axonal diameter, and myelination in WM 36