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One compound that changed, 4-guanidinobutanoate, was also nominally different between the two diet types we evaluated in our previous foodomics analysis 20

The same phenotype was observed in the gbh-1(G283R) and gbh-1(G247Vfs*6) variant nematodes, indicating that gbh-1(G283R) and gbh-1(G247Vfs*6) are pathogenic functional alleles comparable to the knockout allele

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Most of the strongest evidence comes from systematic reviews and network meta-analyses, which pool data from multiple randomized controlled trials to detect patterns that individual studies cannot reliably show