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**If a prohibited substance is administered intravenously or via injection, a TUE is necessary for this substance regardless of whether the infusion or injection is less than 100mL

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Tirzepatides co-agonist activity leads to superior glucose-lowering and weight-loss effects compared to GLP-1 receptor agonists alone Muller, Nature Reviews Drug Discovery Originally developed by Eli Lilly and marketed under the brand name Mounjaro , tirzepatide was first approved by the FDA in 2022 for type 2 diabetes