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Abbreviations ALP: Alkaline phosphatase ALT: Alanine transaminase AST: Aspartate transaminase BatF3: Basic leucine zipper ATF-like transcription factor 3 DAPI: 4,6-diamidino-2-phenylindole GSH: Glutathione EHBD: Extra hepatic bile duct IHBD: Intra hepatic bile duct MDR2: multidrug resistance protein 2 NAC: N -Acetyl-L-Cysteine PSC: Primary sclerosing cholangitis WT: Wild type ZO-1: Zonula occludens-1 References Banales, J

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Further evidence was gathered that, in many different cell systems in vitro, peroxynitrite behaved as a potent modulator of an array of cell signal transduction pathways, independently from its ability to nitrate tyrosine