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These insights suggest that interventions aimed at restoring gut microbiota balancethrough dietary modifications, probiotics, fecal microbiota transplantation, etc.may offer novel therapeutic strategies to alleviate the debilitating symptoms of this complex condition [1, 8]

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These findings echo those of similar rat studies by Khanna and Sharma, 35 Alaei et al, 36 and Kulkarni et al, 23 in which mice injected with morphine twice daily were found to be significantly less likely to develop tolerance and dependence to the drug if they were pre-treated with AA (400-1600 mg/kg)

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