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Am J Transl Res 12:26272639 Chughlay MF, Kramer N, Spearman CW, Werfalli M, Cohen K (2016) N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review

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FIGURE 4 Evidence suggests that aged animals are more susceptible to RGCs loss in models of acute IOP elevation-induced ischemia, optic nerve crush, or laser-induced ocular hypertension (Tan et al., 2015

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108,109 The decrease in mitochondrial membrane potential induces PINK1 aggregation and autophosphorylation on the outer mitochondrial membrane, which recruits Parkin to initiate the PINK1-Parkin mitophagy pathway to remove damaged mitochondria