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A large prospective study on 502,409 ALS patients showed that a high cholesterol/HDL ratio and high LDL and ApoA serum levels were associated with increased ALS risk (Thompson et al., 2022)

has elucidated that OA directly interacts with ornithine decarboxylase 1 (ODC1) at the lysine-78 residue, thereby augmenting ODC1 enzymatic activity and facilitating putrescine synthesis ( Dietary interventions like ketogenic diets and caloric restriction can influence immune function by altering Treg metabolism and differentiation through fatty acid desaturation, nuclear receptor activation, and metabolic pathways

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14 Since aging is one of the leading risk factors for most chronic diseases, it is anticipated that understanding the aging process will facilitate the identification of therapeutic targets for age-related diseases and the development of pharmacological agents suitable for approved clinical use in the future

Jiang's clinic website also stated that BPC-157 had limited human trial data