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The FDA has approved several blood thinners since 2010, including Pradaxa, Xarelto, Eliquis and Savaysa

2 The use of pharmacologic agents has been controversial in the past owing to inconsistent efficacy and the high rate of spontaneous recovery

Metabolism Apixaban: Apixaban is metabolized by O-demethylation, hydroxylation, and sulfation and is primarily mediated by cytochrome P450 enzymes and CYP3A4 and CYP3A5 (7)