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A Call for Improving Research on PainNeuroscience Education and Chronic Pain: An Overview of Systematic Reviews

Regulation of Presynaptic Receptors DA accumulation after MPH blockade of DAT induces disinhibition (upregulation) of the presynaptic receptor DRD2 (dopaminergic neuron) and activates D1 receptors on the postsynaptic neuron that uptake DA, continuing the neuronal transmission and therefore improving attention, focus and organized thoughts and actions [172, 173]