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There were 19 Tier 1 variants representing 13 genes ( PNPLA3, HSD17B13, SAMM50, PARVB, IFNL4, TM6SF2, PEMT, IL-6, MTTP, PPARGC1A, Adiponectin, NR112, and MTHFR )

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Scientific Reports DOI:10.1038/s41598-026-60835-w Abstract Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ) generation during aging

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