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NO is a potent vasodilator, and low levels of intracellular ROS play a crucial role in normal redox signaling that helps to maintain vascular function and integrity under physiological conditions (122)

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Endocytosis, migration, and recycling are among the dynamic processes involved in TJ assembly and disassembly, each of which are modulated by enzymes of various signalling pathways including protein kinase C, mitogen-activated protein kinases, Rho GTPases and myosin light chain kinases (Ulluwishewa et al