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To view a copy of this license, visit About this article Cite this article Kelly, R.A., Leedale, J., Calleja, D

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In this work, we develop a peptide-ferriporphyrin conjugate with tumour microenvironment specific activation for improved tumor penetration and endocytosis, which enables effective inhibition of GPX4 due to the assembly enhanced binding (AEB) effect, ultimately improving its anticancer activity via ferroptosis (Fig

MERRF affects multiple systems and typically presents with myoclonus as the initial symptom, followed by generalized seizures, ataxia, fatigue, motor intolerance, and dementia

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Major neurological disorders like PD arise not from a single large genetic defect but from the interplay of multiple minor genetic factors and environmental influences, collectively forming a complex pathological network ( This review systematically explores the multi-target mechanisms of neuroprotective plant extracts in PD treatment