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doi: 10.1073/pnas.0604056103

doi: 10.3892/or.2017.6014 95 MedjberKFreidjaMLGreletSLorenzatoMMaoucheKNawrocki-RabyBet al

Higher concentration doesn't automatically mean better results and can increase irritation risk

For example, ferroptotic macrophages have the ability to generate HMGB1, a DAMP that triggers the release of pro-inflammatory cytokines, including IL-1 and IL-18, and activates the inflammasome (61)