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That becomes the reference range

This progression makes sense given that thinner skin requires less structural rebuilding to show visible change

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It has also been shown in research to activate the CREB/PGC-1-alpha pathway, which plays a role in suppressing neuroinflammation by reducing pro-inflammatory cytokines and promoting anti-inflammatory mediators

[1] In young animals, the greatest improvements were observed with high-dose paraxanthine (PXN HIGH), outperforming all other groups

Biol Psychiatry (2010) 67:10106.10.1016/j.biopsych.2009.12.004 256 McCullumsmithREKristiansenLVBeneytoMScarrEDeanBMeador-WoodruffJH