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The reclassification to Category 2 may serve as a catalyst for pharmaceutical companies and research institutions to invest in the rigorous clinical trials required for formal FDA approval

Imaging Studies: Liver Imaging : Imaging ultrasound, CT scans, or MRI may assess liver size

For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24