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JAMA (2015) 314(1):4151

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No new antibiotics have been produced in over 40 years, mainly because the big pharmaceutical companies have retreated from their antibiotic research programs due to the lack of incentives [143]

doi: 10.3389/fmicb.2024.1378989 Received 30 January 2024 Accepted 29 February 2024 Published 13 March 2024 Volume 15 - 2024 Edited by Jose Martin Arguello, Worcester Polytechnic Institute, United States Reviewed by Viviana Andrea Rapisarda, Facultad de Bioqumica, Qumica y Farmacia (UNT), Argentina Soufian Ouchane, Centre National de la Recherche Scientifique (CNRS), France Brenda Valderrama, National Autonomous University of Mexico, Mexico Updates Copyright 2024 Mingers, Barthels, Mass, Acua, Biedendieck, Cooke, Dailey, Gerdes, Blankenfeldt, Dailey, Warren, Jahn and Jahn

24-hour recovery (MRC-5) Result:Reduced p53 protein levels, depleted cytochrome c, and caused differential expression of RBBP6 isoforms (isoform 1 expressed in first 24 h of treatment and depleted during recovery, isoform 3 upregulated during recovery) in MRC-5 fibroblasts with combination treatment