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The effects of a drug in the body depend on various factors including body composition, age, stress, gender, race, diet, medication, hormonal state, pathophysiological states, long-term alcohol consumption and smoking that modify fundamental processes determining a drugs pharmacokinetic and pharmacodynamic profiles (137)

Remyelination is enhanced by Astragalus polysaccharides through inducing the differentiation of oligodendrocytes from neural stem cells in cuprizone model of demyelination

reported the therapeutic potential of another natural quinazoline derivative that promoted oxidative stress and increased ROS production [113]

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Gastric acid has a pH of 1 to 2, a force that would dissolve most tissues in the body