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PBMC isolation Peripheral blood was collected in EDTA-containing tubes and PBMCs were isolated using SepMate-50 tubes according to the manufacturers protocol (STEMCELL Technologies)

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Development and trends in metabolomics studies in psoriasis: a bibliometric analysis of related research from 2011 to 2024

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)